Salmon DNA obtained by pure hyaluronic acid and sperm of salmon fish is applied to provide cellule re-juvenescence on skin. Vaccine of Salmon DNA serums helps neutralize aging effects of sun and environmental factors on skin. Salmon fish milk applied in the method of skin rejuvenation with Salmon DNA also meets different vitamin needs of the skin. Salmon DNA treatment could be applied 2-4 sessions in once every 15 days per needs of skin and each session takes 15-30 minutes. After the treatment, patient could continue daily life without having any sign of operation on skin.